About me
Dr. Qian Zhang （张潜） joined the Department of Chemistry at Xi'an Jiaotong-Liverpool University in November 2020 as Assistant Professor. He studied his Ph.D. with Professor Cheng-Wei Tom Chang at the Utah State University, investigating the synthesis of new aminoglycosides. He then had the experience of conducting post-doc research at the University of Notre Dame with Professor Shahriar Mobashery for one year. Before taking this position, he had four years of experience working in a pharmaceutical company. His research focuses on developing new methodologies in organic chemistry and synthesizing bioactive small molecules.
Creating new staff is fun!
Qian Zhang's groups
Research Interest
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Synthesis of hybrid molecules with multi-targeting properties
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Green chemistry
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Carbohydrates chemistry
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New methodology development in organic chemistry
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Electrosynthesis
Grants
- PI. Fees-Only Scholarship: FOSA2312010. "Dehydration Reactions Under Reduced Pressure by Using a Rotary Evaporator", 300 000.00 RMB
- PI. Summer Undergraduate Research Fellowship (SURF), SURF-2023-0007, "Rotary-Evaporator-Assisted Ester Synthesis " 6 000.00 RMB.
- PI. FOSA2212021,"Synthesis of Amoxicillin-Metronidazole Hybrid Antibiotic Against Helicobacter pylori "240 000.00 RMB.
- PI. Summer Undergraduate Research Fellowship (SURF), CODE 2022147, "Green synthesis of small molecules using natural lemon juice " 6 000.00 RMB.
- PI. PGRS2112027, "Design, Synthesis and Evaluation of Aminoglycoside-Oxazolidinone Dual-targeting Hybrid Antibiotics" 420 000.00 RMB
- PI. Research Development Fund (RDF), Ref No.: RDF-20-02-30, "The synthesis of lipid antigens for the detection of mycobacterial infections" 100 000.00 RMB. Start date 09/01/2021
- PI. Summer Undergraduate Research Fellowship (SURF), SURR CODE:2021102. "Synthesis of small molecules using water as the solvent" 7 500.00 RMB
Publications
After Joining XJTLU:
Yinzhe Chen (PhD), Weiding Wang (PhD, WD Wang and YZ Chen contribute equally), Haotian Qin (SURF), Rui Liu (SURF), Qian Zhang*, Solvent-Free and under Vacuum O-Benzylation of Carboxylic Acids by Using a Rotary Evaporator, ChemistrySelect, Volume8, Issue47 December 18, 2023, e202304145. DOI: 10.1002/slct.202304145
Weiding Wang (MRes), Yinzhe Chen (PhD), Xiaoheng Li (FYP2022), Qian Zhang* (2023). A green deprotection strategy: Removing acid-labile protecting groups using lemon juice/ethanol as the solvent. Tetrahedron Green Chem, 100026. https://doi.org/10.1016/j.tgchem.2023.100026
Weiding Wang (MRes), Cheng-Wei Tom Chang, Qian Zhang*. 1,4-Naphthoquinone Analogs and Their Application as Antibacterial Agents. ChemistrySelect. Volume7, Issue43, 2022, e20220333. https://doi.org/10.1002/slct.202203330
Keyin Wang (FYP 2021), Yinzhe Chen (KY Wang and YZ Chen contribute equally), Siyuan Wang, Qian Zhang*."A Convenient Synthesis of Linezolid through Buchwald-Hartwig Amination" Tetrahedron Letters 105 (2022) 154050. https://doi.org/10.1016/j.tetlet.2022.154050
Tang R, Liu J, Li S, Zhang J, Yu C, Liu H, Chen F, Lv L, Zhang Q, Yuan K, Shao H. A patent and literature review of CDK12 inhibitors. Expert Opinion on Therapeutic Patents. 2022 Oct 3;32(10):1055-65.
Before Joining XJTLU
- Zhang, Qian, Xinrui Peng, Michelle Grilley, Jon Y. Takemoto, and Cheng-Wei Tom Chang. "Using fluorogenic probes for the investigation of selective biomass degradation by fungi." Green Chemistry 17, no. 3 (2015): 1918-1925.
- Zhang, Qian, Madher N. Alfindee, Jaya P. Shrestha, Vincent de Paul Nzuwah Nziko, Yukie Kawasaki, Xinrui Peng, Jon Y. Takemoto, and Cheng-Wei Tom Chang. "Divergent synthesis of three classes of antifungal amphiphilic kanamycin derivatives." The Journal of Organic Chemistry 81, no. 22 (2016): 10651-10663.
- Zhang, Qian, Jaya P. Shrestha, and Cheng-Wei Tom Chang. "Synthesis of bioactive 1-alkyl-1H-naphtho [2, 3-d][1, 2, 3] triazole-4, 9-diones and N-aryl-2-aminomethylene-1, 3-indanediones using water as the solvent." Tetrahedron Letters 55, no. 10 (2014): 1839-1842.
- Zhang, Qian, and Cheng-Wei Tom Chang. "Divergent and facile Lewis acid-mediated synthesis of N-alkyl 2-aminomethylene-1, 3-indanediones and 2-alkylamino-1, 4-naphthoquinones." Tetrahedron Letters 56, no. 7 (2015): 893-896.
- Zhuang, Zhijun, Dawei Wan, Jun Ding, Shijie He, Qian Zhang, Xiaomei Wang, Ying Yuan et al. "Synergistic Activity of Nitroimidazole-Oxazolidinone Conjugates against Anaerobic Bacteria." Molecules 25, no. 10 (2020): 2431.
- AlFindee, Madher N., Qian Zhang, Yagya Prasad Subedi, Jaya P. Shrestha, Yukie Kawasaki, Michelle Grilley, Jon Y. Takemoto, and Cheng-Wei Tom Chang. "One-step synthesis of carbohydrate esters as antibacterial and antifungal agents." Bioorganic & medicinal chemistry 26, no. 3 (2018): 765-774.
- Fosso, Marina, Madher N. AlFindee, Qian Zhang, Vincent de Paul Nzuwah Nziko, Yukie Kawasaki, Sanjib K. Shrestha, Jeremiah Bearss, Rylee Gregory, Jon Y. Takemoto, and Cheng-Wei Tom Chang. "Structure–activity relationships for antibacterial to antifungal conversion of kanamycin to amphiphilic analogues." The Journal of organic chemistry 80, no. 9 (2015): 4398-4411.
- Lee, Stephen T., Benedict T. Green, Kevin D. Welch, Glenn T. Jordan, Qian Zhang, Kip E. Panter, David Hughes, Cheng-Wei Tom Chang, James A. Pfister, and Dale R. Gardner. "Stereoselective potencies and relative toxicities of γ-coniceine and N-methylconiine enantiomers." Chemical Research in Toxicology 26, no. 4 (2013): 616-621.
- Zhang, Shuwei, Siyuan Wang, Qian Zhang, Cheng-Wei Tom Chang, and Jixun Zhan. "Three new fusidic acid derivatives and their antibacterial activity." Bioorganic & medicinal chemistry letters 25, no. 9 (2015): 1920-1924.
- Sun, Lei, Siyuan Wang, Shuwei Zhang, Lei Shao, Qian Zhang, Chad Skidmore, Cheng-Wei Tom Chang, Dayu Yu, and Jixun Zhan. "Characterization of three tailoring enzymes in dutomycin biosynthesis and generation of a potent antibacterial analogue." ACS chemical biology 11, no. 7 (2016): 1992-2001.